In Search of Putative FOXP3+ Cell Surface Markers
ByStephen Jones
Alternative RSS Feed
Despite intense interest and scrutiny focused on FOXP3 as a key protein & master transcription factor, isolating and enriching for viable FOXP3 positive cells remains a challenge. Although cell separation/staining via CD4+CD25+ selection is commonly used, this technique has limited applications. Thus, surface markers specific for FOXP3 positive cells would be invaluable research tools as they would:
• Facilitate isolation & purification of viable
Treg cells
• Distinguish naturally occurring
CD4+CD25+cells from both naive and
recently activated CD4+CD25-
nonregulatory T cells
• Allow therapeutic manipulation of
Treg cells
As the search for putative FOXP3+ markers continue, Neuropilin-1, GPR83, & FR4 have emerged as potential candidates. IMGENEX is excited to offer a panel of flow cytometric characterized antibodies against:
• Neuropilin-1 (clone 211H6.01)
• GPR83 (polyclonal)
• Folate Receptor 4 (clones 12A5 & TH6)
Flow cytometric analysis of intracellular FOXP3 (IMG-5802D) and cell surface FR4 with clone 12A5 (IMG-6217C) (left) and clone TH6 (IMG-6218C) (right) at 0.06 ug/10^6 mouse splenocytes.
Flow cytometric analysis of Neuropilin-1 in CD4+CD25+ human PBMCs using A) an isotype control & B) DDX0440 at 0.5 ug/10^6 cells. These antibodies are available in multiple sizes and conjugates.
IMGENEX India Pvt Ltd. the only biotech company in Orissa and one of its kinds in Eastern India. IMGENEX India started in Oct as an outsourcing branch of IMGENEX Corporation, San Diego, USA. Find out more information about FOXP3+ Cell Surface Markers.
Related Articles, Information, Products And Links
Related Articles on Alternative
- Massage Therapy
- Machines a sous et art
- The Science of Life I
- The Science of Life II
- TLR1- cluster of differentiation 281
- TLR10- cluster of differentiation 290
- TLR2- cluster of differentiation 282
- TLR3- cluster of differentiation 283
- Benefits Of Fish Oils Supplements
- Benefits Of Eating Vegetables
- TLR4- cluster of differentiation 284
- TLR5- cluster of differentiation 285
- TLR6- cluster of differentiation 286
- TLR7- cluster of differentiation 287
- TLR8- cluster of differentiation 288
- TLR9- cluster of differentiation 289
- Dry Eyes A Common Problem
- Chiropractor
- Procerin Reviews
- What Is Neem?
Latest Articles on Alternative
-
Benefits Of Eating Vegetables
Vegetarian trail mix can be made at home and stuffed in premade bags to grab on the go. Because you are including your own raw almonds, raisins, pumpkin seeds and sunflower seeds for a nutritious healthy snack you aren't including other high calorie nuts or chocolate chips that some of the prepackaged trail mixes include.... -
Benefits Of Fish Oils Supplements
Fish oil supplements are unarguably among the most important dietary supplements as they are the richest source of omega-3 fats. They are totally natural and they rank high in terms of purity as they are derived directly from the fish.With the recent increase in people taking fish oil supplements.... -
Ways To Control Obesity
Obesity in children and teenagers has far reaching health implications that we are today just beginning to unravel. Diseases such as Type 2 diabetes, heart disease, certain cancers, and so on are lying in wait for the teenager who allows her weight to spiral out of control.... -
Warts On Hands
Common warts are the most seen warts on people.Dogs and cats can also get common warts. Some people believe that common warts are caused by frogs, this is not true. Common warts tend to be caused by an overgrowth of skin cells on the outside of the skin causing a lump to appear.... -
Canker Sores Treatment Tips
Canker sores are mouth ulcers which are an open sore found in the mucus membrane skins inside the lips, cheeks, on the roof of the mouth, and on the underside of the tongue. These painful sores can also be found on the soft palate and the tonsil areas.... -
How To Get Healthy Skin
We can't deny the fact that in this world of beauty magazines, you would always feel that there is a need to look good. But what would you feel when there are red oily humps on your face? Of course, this would greatly affect your self-confidence and outlook on life.... -
Enhance The Breasts
Some women have discovered that one of the ways to enhance breasts is to take estrogen-based birth control pills or nurse a baby, but these effects do not last. Estrogen-based natural enhancement supplements with multiple herb combinations can yield better results. If you want to know how to enhance breasts naturally,... -
Breast Reduction And Lift
Women with very large, pendulous breasts may experience a variety of medical problems caused by the excessive weight, from back and neck pain and skin irritation to skeletal deformities and breathing problems. And unusually large breasts can make a woman breast-feeding feel extremely self-conscious. Breast reduction, technically known as reduction mammaplasty, is designed for such women.... -
Treatment For Removing Scars
In recent years these have begun to gain widespread popularity as the modern way for treating acne scars. The properties of the copper peptides help to improve the skins elasticity as well as firm it up. Plus it helps to neutralize those free radicals which can cause damage to your skin as it contains anti-oxidant properties.... -
How To Treat Breast Cancer
Breast cancer affects one in eight women during their lifetime; incredibly, it is estimated that just over a million people throughout the world - women and men alike - will be diagnosed during this year alone. Breast cancer treatment depends on how advanced the cancer is....
